The Materials Research Department (MRD), home to the AFRICA-NANOAFNET Network and Accelerator for Sustainable Development in Africa (ASDA), has been a pioneer in South Africa's nuclear and materials research since the 1960s. From the first 6.0 MV Van de Graaff (VDG) accelerator to the newly commissioned 3.0 MV Tandetron Accelerator, MRD has continuously advanced low-energy nuclear physics and ion-beam research. These cutting-edge innovations, from nanotechnology to biotechnology, have played a critical role in socio-economic development and human capacity building, particularly for South Africa’s previously disadvantaged communities. With a renewed commitment to producing world-class PhD graduates, MRD remains at the forefront of global materials science research.