Auger electrons emitted by iodine-123

Research development work is ongoing to study the biological damage of Auger electrons emitted by iodine-123 for use in radiation therapy. These particles travel only in the nanometre range – a distance comparable to the diameter of a DNA molecule.  Recently an organic compound was successfully synthesised as a pre-cursor for radiolabelling that will ensure the up-take of iodine-123 into the DNA of cells. For this a tributyl tin group was attached to a DNA building block derivative with excellent purity. This is needed to ensure high radiolabelling efficiency. The structure of the pre-cursor was confirmed by nuclear magnetic resonance spectroscopy.