Radiation Biophysics – Publications

RADIATION BIOPHYSICS PUBLICATIONS

J Gueulette, B de Coster, A Wambersie J Slabbert , L Bohm D Jones.
The RBE of the 200 MeV proton beam produced at the National Accelerator Centre of Faure (RSA) for late lung tolerance in mice after single and fractionated irradiation.

Proc. Second Int. Symp. On Hadrontherapy, PSI and CERN 1998 (Elsevier BV, Amsterdam).

J P Slabbert, T Theron, D Jones, G Schmitt.
Need to augment the high-LET characteristics of a p(66)/Be neutron beam.
Advances in Neutron Capture Therapy Vol. II, Chemistry and Biology. Eds. B Larsson (Elsevier Science, Amsterdam 1998)

Slabbert J.P., J.H. Langenhoven and B.S. Smit (1999).
Synthesis of [123I]Iodoantipyrine to study the high-LET characteristics of Auger electrons in mammalian cells.

Journal of Radioanalytical and Nuclear Chemistry 240, 505-508.

J P Slabbert, J H Langenhoven and B Smit.
The high-LET characteristics of Auger electrons as observed in mammalian cells using [123I]Iodoantipyrine.

Proc. First Int. Symp. On Nuclear and Related Techniques in Agriculture, Industry, Health and Environment. Vol II Radiofarmacia (Cuba1998).

J P Slabbert, T Theron, F Zölzer, C Streffer, L Böhm.
A comparison of the potential therapeutic gain of p(66)/Be neutrons and d(14)/Be neutrons.
Int. J of Rad. Oncol. Biol Phys. 47 (4) (2000) 1059-1065.

J Gueulette, L Böhm, J P. Slabbert, B M. De Coster, G S. Rutherfoord, A Ruifrok, M Octave-Prignot, P J. Binns, A. N Schreuder, J E. Symons, P Scalliet, D T L Jones
Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractionated doses.

Int. J of Radiat. Oncol. Biol. Phys. 47 (4) (2000) 1051-1058.

J M Akudugu, J P Slabbert, A Serafin, L Bohm.
Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival.
Radiation Research 153: 62-76, 2000.

B S Smit, J P Slabbert, S A Reinecke, L Bohm.
Comparison of cell inactivation by Auger electrons using the two reagents 4-[123I]iodoantipyrine and [123I]NaI.

Radiation and Environmental Biophysics 40: 47-52,2001.

J-P Pignol, J P Slabbert, P Binns (2001).
Monte Carlo simulation of fast neutron spectra: Mean lineal energy estimation with an effectiveness function and correlation to RBE.

Int. J of Radiat. Oncol. Biol Phys. 49, 251-260.

J Gueulette, J Slabbert, L. Böhm, B de Coster, J-F Rosier, M Octave-Prignot, A Ruifrok, A N Schreuder, A Wambersie, P Scalliet, DTL Jones. (2001)
Proton RBE for early intestinal tolerance in mice after fractionated irradiations. Crypt regeneration study for fractionated proton irradiations.
Int. J. Radiotherapy and Oncology 61, 177 – 184

J- P Pignol, J P Slabbert (2001)
Recoil proton, alpha particle and heavy ion impacts on microdosimetry and RBE of fast neutrons: Analysis of KERMA spectra calculated by Monte Carlo simulation.

Canadian J. Physiol. Pharmacol. 79 189 – 195.

F J Vernimmen, J K. Harris, J A. Wilson, R Melvill, B J Smit, J P Slabbert (2001).
Stereotactic proton beam therapy of skull base meningiomas
Int. J. of Radiat Oncol Biol. Phys. 49, 99-105.

B S Smit, J P Slabbert, S A Reinecke, L Bohm.
Comparison of cell inactivation by Auger electrons using the two reagents 4-[123I]iodoantipyrine and [123I]NaI.

Radiation and Environmental Biophysics 40: 47-52,2001.

Slabbert J.P., T. Theron, F. Zölzer, C. Streffer and L. Böhm (2000).
A comparison of the potential therapeutic gain of p(66)/Be neutrons and d(14)/Be neutrons.

Int. J. Radiat. Oncol. Biol. Phys. 47, 1059-1065.

Gueulette J., L. Böhm, J.P. Slabbert, B.M. De Coster, G.S. Rutherfoord, A. Ruifrok, M. Octave-Prignot, P.J. Binns, A.N. Schreuder, J.E. Symons, P. Scalliet, D.T.L. Jones (2000).
Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractionated doses.

Int. J. Radiat. Oncol. Biol. Phys. 47, 1051-1058.

Akudugu J.M., J.P. Slabbert and L. Bohm (2000).
Frequency of radiation-induced micronuclei frequency in neuronal cells does not correlate with clonogenic survival.

Radiation Research 153, 62-67.

S Bloem, J Carpenter, J H Hofmeyr.
Radiation Biology and Inherited sterility in False Codling Moth
J Econ. Entomol. (2003) 96 (6), 1724 – 1731

Serafin AM, Akudugu JM, Bohm L. (2002)
Drug resistance in prostate cancer cell lines is influenced by androgen dependence and p53 status.

Urol. Res. 30: 289-294

Serafin AM, Akudugu JM, Bohm L. (2003)
Studies on the influence of DNA repair on radiosensitivity in prostate cell lines.

Urol. Res. 31: 227-231

Akudugu JM, Binder AB, Serafin A, Slabbert J, Giese A, Böhm L. (2004)
Changes in G1-phase population in human glioma and neuroblastoma cell lines influence p(66)/Be neutron-induced micronucleus yield.

Life Sciences (in press).

Akudugu JM, Slabbert JP, Roos WP, Bohm L. (2003)
Micronucleus response of human glioblastoma and neuroblastoma cells toward low-LET photon and high-LET p(66)/Be neutron irradiation.
Am J Clin Oncol 26(3) 1-6

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Murray Em, Werner Id, Schmitt G, Stannard C, Gudgeon A, Wilson J, Fredericks S, Mcevoy E, Nel E, Hunter A, Slabbert J P. (2004)
Neutron Versus Photon Radiotherapy For Local Control In Inoperable Breast Cancer.
Strahlentherapie Und Onkologie (Accepted For Publication )

F Vernimmen, J P Slabbert, J Wilson, S Fredericks, R Melvill. (2004)
Stereotactic proton beam therapy for large intracranial arteriovenous malformations.
INT. J. RADIATION ONCOLOGY. BIOL. PHYS. (ACCEPTED FOR PUBLICATION)

Research Activities Reported at International Conferences

Steoreotactic Proton Beam Radiotherapy for Acoustic Neuromas. Z Mohamed, F Vernimmen, J Slabbert. PTCOG 40, Paris, France 16 – 19 June 2004.

Radiobiological considerations in radiotherapy. JP Slabbert (2002)
PTCOG XXXVII and workshop 28 – 30 October, Cape Town

Radiosensitisation of neutron damage using a halogenated pyrimidine.
JP Slabbert, A Lennox, S Smit, D Jones. (2002) PTCOG XXXVII and workshop 28 – 30 October, Cape Town

Micronucleus response of human glioma cells to low LET photons and high LET neutrons. JM Akudugu, JP Slabbert, WP Roos, L. Bohm (2002). PTCOG XXXVII and workshop 28 – 30 October, Cape Town

Akudugu JM, Theron T, Böhm L: Influence of DNA double-strand-break repair on micronucleus yield in human glioblastoma cell lines. DEGRO 2001, Hamburg, Germany, September 2001.

Akudugu JM, Slabbert JP, Roos WP, Böhm L: Dose response relationships of p(66)/Be neutron and 60Co g induced micronuclei in human glioma and neuroblastoma cell lines. ESRB, Dresden, Germany, September 2001.

ESRB, Dresden, Germany, September 2001
Akudugu JM, Slabbert JP, Roos WP, Böhm L:
Dose response relationships of p(66)/Be neutron and 60Co g induced micronuclei in human glioma and neuroblastoma cell lines.

DEGRO 2001, Hamburg, Germany, September 2001.
Akudugu JM, Theron T, Böhm L:
Influence of DNA double-strand-break repair on micronucleus yield in human glioblastoma cell lines.

5th International Stereotactic Radiosurgery Society Congress, June 2001, Las Vegas USA
F J Vernimmen, J P Slabbert, J Wilson, J Harris, S Schroeder (2001). Clinical determination of the alpha/beta value of radiosurgical target tissues.

Pignol J-P and J. P. Slabbert. Monte Carlo simulations of fast neutron spectra, mean lineal energy estimations with an effectiveness function and correlation to RBE. Fourth Congress of Fundamental Radiobiology and Applications, Saint Francois, Guadeloupe, December 1999.

Smit B.S., J.P. Slabbert and L Böhm (1999). Radiotoxicity of Auger electrons in two tumour cell lines. 11th International Congress of Radiation Research, Dublin, Ireland, July 1999.

Meehan K., M.I. Parker, J.P. Slabbert and R. Louw (1999). Evaluation of DNA damage in a population of bats residing in an abandoned monazite mine. 11th International Congress of Radiation Research, Dublin, Ireland, July 1999.

Slabbert J.P., C. Theron, F. Zolzer, D.T.L. Jones, L. Bohm, G. Schmitt and C. Streffer. A comparison between the potential therapeutic gain of p(66)/Be and d(14)/Be neutrons. International PTCOG meeting. Cape Town, April 1999.

Pignol J-P, P. Paquis, R. Sabbattier, A. Lennox, D.T.L. Jones, J.P. Slabbert, C.M.B. Diop and N. Breteau (1998). BNCEFN optimisation with lead block collimation and graphite embedding the Monte Carlo simulation intercomparison of various fast neutron beams. Proc. Eighth Int. Symp. On Neutron Capture Therapy for Cancer, La Jolla California

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Research Activities Reported at Local Conferences

Cancer Association of South Africa Oncology School on Particle Therapy, NAC, February 1999.

J P Slabbert. The Basic radiobiology of neutrons: Rationale for neutron therapy.

J P Slabbert. The RBE for protons for acute reactions.

T Theron, J P Slabbert, A Serafin, L Bohm. Paradoxes in the radiosensitivity of cells to photons or neutrons.

L Bohm, J Gueulette, B M de Coster, J P Slabbert, D Jones. The late effects of the NAC proton beam in mouse lung.

South African Association of Physicists in Medicine and Biology Congress, Durban, June 2000.

B.S. Smit, J.P. Slabbert, S. Dolley, S.A. Reinecke and L. Böhm. Auger electron damage in cells with different radiosensitivities.

C. Michelet, J.P.Slabbert, Ph. Moretto, W.J. Przybylowicz, C.A. Pineda and C.L. Churms. A new single ion irradiation facility: Technical developments.

J. M. Akudugu, J.P. Slabbert and L. Böhm. An examination of seven neuronal cell lines for the interrelationship between micronucleation, apoptosis and reproductive cell death.

B. Ntuane, J.P. Slabbert and J. Symons. Chemical protection against fast neutron damage.

H. Burger, A.J. van Rensburg, J.P. Slabbert, E. Kreft and G. Joone. Preliminary study: A static transverse magnetic field as photon beam radiation response modifier.

Radiobiology 2000, 1st International Congress of the South African Radiobiological Society, Stellenbosch, December 2000.

J P Slabbert. Biological Dosimetry for radiation workers – the South African experience.

B.S. Smit, J.P. Slabbert, S. Dolley, S.A. Reinecke and L. Böhm. Cellular radiosensitivity in response to Auger electrons from Iodine-123.

K.A. Meehan, E.J. Truter, J.P. Slabbert, R. Louw and M.I. Parker. Evaluation of DNA damage in a population of bats (Chiroptera) residing in an abandoned monazite mine.

N. Falzone, J.C. Swarts, J.P. Slabbert, C.E.J van Rensburg. Radiation effects of a novel Rh-complex on CHO cells in vitro.

J Akudugu, J.P. Slabbert and L. Böhm. Micronucleation apoptosis and reproductive death in neuronal cells.

2nd National Nuclear Technology Conference, Faure, May 2001.

J P Slabbert, A Lennox, B S Smit and DTL Jones. Radiosensitisation of neutron damage using a halogenated pyrimidine.
J P Slabbert, D K Eyles, B S Smit and B N Barnes. Chemical Dosimetry for a Newly Installed 60Co Irradiator at ARC Infruitec-Nietvoorbij.

SAAPMB 41st Congress Bloemfontein, June 2001
Akudugu JM, Slabbert JP, Roos WP, Böhm L: Dose response relationships of p(66)/Be neutron and 60Co g induced micronuclei in human glioma and neuroblastoma cell lines.

J P Slabbert, A Lennox, B S Smit and DTL Jones. Radiosensitization of neutron damage using a halogenated pyrimidine.

Lecture Course in Radiobiology of Radionuclides July 2001. – M. Med (Nuclear Medicine) J P Slabbert. Registrars from Tanzania, Sudan, Namibia and Unv. Stellenbosch.

IAEA AFRA Meeting, Southern Africa Institute of Welding, Johannesburg. August 2001
J P Slabbert. Biological Dosimetry for Industrial Radiographers.

47th Academic Day of the University of Stellenbosch 20 – 21 August 2003

1. Response of CHO-K1 cells to gamma and neutron radiation as measured by single cell gel electrophoresis. Smit K A, Slabbert J P, Meehan K A. (Abstract No 185)
2. Comet formation in lymphocytes induced by neutron and gamma radiation. Rossouw M S, Meehan K A, Slabbert J P, Groenewald W A. (Abstract No 161).

42nd Meeting of the SAAPMB, held at iThemba LABS, 10-13 June 2003.

i Response of CHO-K1 cells to gamma and neutron radiation as measured by single cell gel electrophoresis (SCGE). K A Smit, J P Slabbert, K A Meehan

ii Radiolabelled monoclonal antibodies to image ovarian adenocarcinoma.
JH Neethling, E J Truter, D D Rossouw, J P Slabbert

iii Comet formation in lymphocytes induced by neutron and gamma irradiation. MS Rossouw, K A Meehan, WAG Groenewald, J P Slabbert

10th Annual Congress of the South African Society of Nuclear Medicine (Stellenbosch 3-7 December 2002).

LABELLING OF MONOCLONAL ANTIBODIES FOR RADIOIMMUNOTHERAPY
Neethling JH 1 , Truter EJ 1 , Rossouw DD, Slabbert JP , Smit BS

SAAPMB Congress Mount Amanzi: 30 July – 2 August 2002

(i) Residual Cellular Damage as a Measure of Radiation Dose. JP Slabbert (invited talk)

(ii) Radiosensitization by bromodeoxyuridine in cells irradiated with different ionisation densities. KK Nkuna, JP Slabbert, B S Smit, J Symons.

(iii) The influence of neutron energy on micronucleus yield and potential therapeutic gain. BW Weber, JP Slabbert, J Akudugu, L Bohm

Akudugu JM, Slabbert JP, Roos WP, Böhm L: Dose response relationships of p(66)/Be neutron and 60Co g induced micronuclei in human glioma and neuroblastoma cell lines. SAAPMB 41st Congress Bloemfontein, June 2001.

J P Slabbert, A Lennox, B S Smit and DTL Jones. Radiosensitization of neutron damage using a halogenated pyrimidine. SAAPMB 41st Congress Bloemfontein, June 2001.

J P Slabbert, A Lennox, B S Smit and DTL Jones. Radiosensitization of neutron damage using a halogenated pyrimidine. 2nd National Nuclear Technology Conference, May 2001.

J P Slabbert, D K Eyles, B S Smit and B N Barnes. Chemical Dosimetry for a Newly Installed 60Co Irradiator at ARC Infruitec-Nietvoorbij. 2nd National Nuclear Technology Conference, May 2001.

 

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